Cause-Specific Cardiovascular Risk Associated With Nonsteroidal Antiinflammatory Drugs Among Healthy Individuals
نویسندگان
چکیده
منابع مشابه
Cause-specific cardiovascular risk associated with nonsteroidal antiinflammatory drugs among healthy individuals.
BACKGROUND Studies have raised concern on the cardiovascular safety of nonsteroidal antiinflammatory drugs (NSAIDs). We studied safety of NSAID therapy in a nationwide cohort of healthy individuals. METHODS AND RESULTS With the use of individual-level linkage of nationwide administrative registers, we identified a cohort of individuals without hospitalizations 5 years before first prescriptio...
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BACKGROUND Non steroidal anti-inflammatory drugs (NSAIDs) increase mortality and morbidity after myocardial infarction (MI). We examined cause-specific mortality and morbidity associated with NSAIDs in a nationwide cohort of MI patients. METHODS AND RESULTS By individual-level linkage of nationwide registries of hospitalization and drug dispensing from pharmacies in Denmark, patients aged >30...
متن کاملRisk of lung carcinoma among users of nonsteroidal antiinflammatory drugs.
BACKGROUND Nonsteroidal antiinflammatory drugs (NSAIDs) inhibit the development of lung tumors in experimental animals. To the authors' knowledge there are little data regarding whether regular use of NSAIDs reduces the risk of developing lung carcinoma in humans. METHODS The association between lung carcinoma risk and regular use of NSAIDs, including aspirin, was evaluated in a hospital-base...
متن کاملNonsteroidal Antiinflammatory Drugs are Associated with Increased Aortic Stiffness
OBJECTIVES Nonsteroidal antiinflammatory drugs (NSAIDS) have been shown to retard aneurysm growth in animal models. In vitro studies have shown an inhibitory effect of NSAIDS on matrix metalloproteinase-9, interleukin-1beta, and IL-6 mediated arterial wall elastolysis. The aim of this study was to investigate the effects of NSAIDs on arterial stiffness, a surrogate marker of elastolysis. METH...
متن کاملUse of Nonsteroidal Antiinflammatory Drugs
Clinical trial data have prompted questions about the degree to which patients and their physicians should consider an increased risk of cardiovascular or cerebrovascular events when selecting medications for pain relief. Since the 2005 publication of a Science Advisory on the use of nonsteroidal antiinflammatory drugs (NSAIDs) by the American Heart Association,1 several important events have o...
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ژورنال
عنوان ژورنال: Circulation: Cardiovascular Quality and Outcomes
سال: 2010
ISSN: 1941-7713,1941-7705
DOI: 10.1161/circoutcomes.109.861104